BIOC 406 Lecture Notes - Lecture 11: Phosphoribosyl Pyrophosphate, Purine, Glutamine
Document Summary
Purine synthesis: production of 5"-phospho-beta-d-ribosylamine is the comminted step. You have ribose-5-phosphate that comes from the pentose phosphate pathway. -> prpp synthase will ac then you have the commibed step of purine synthesis: gln-prpp amino-transferase. It"s libera n10-formyl-thf will donate a carbon and the ring will close. This is an energy requiring process (4 or 5 atps) At the end of this sequence of steps, you get inosine-5"-monophosphate. This will be changed to give you either amp or gmp. Purine biosynthic enzymes associate in vivo when prurine biosynthesis is active. Purinosome: enzyme fused with gfp which is uorescent protein.
