MCB 10 Lecture Notes - Lecture 8: Covalent Bond, Guanine, Thymine
25 Sep 2016
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Lecture 8 dna: linkage mapping: n trios = 2n chromosomes that underwent meiosis in parents (parents and one child) Ex: 2 markers x and y n = 35 trios, 6 x-y recombinant chromosomes from fathers, 7 x-y recombinant chromosomes from mothers. Fraction of recombination: (6+7)/70 = 0. 186 = 18. 6% = 18. 6cm. Ex: jane is healthy but her father has an x-linked recessive disorder, hemophilia. Probability is : history of dna, dna double helix described by james watson and francis crick (1953) Central dogma dna rna protein (crick talked at ucl, 1957) Early 1960s: mrna discovered, triplet genetic code postulated. Late 1960s: crick, sydney brenner and others decipher the codons for all 20 amino acids: molecular definition of a gene, gene a segment of dna; it directs the formation of rna to produce proteins. The protein (or functional rna) creates the phenotype.
