BIO SCI 38 Lecture Notes - Lecture 1: Viral Vector, Memory Consolidation, Nmda Receptor Antagonist
13 Jan 2020
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Viral vectors are like viruses, but only express experimental genes of interest and often a fluorescent marker protein. Block expression of one specific gene in the cell, 2) over-express a specific gene, 3) allow the experimenter to optically image neural activity, or 4) allow the experimenter to manipulate neural circuits. Determine whether molecular changes seen following ltp induction also occur in the brain after learning. Determine whether blocking molecular processes necessary for ltp also block learning or memory consolidation. Determine whether learning increases synaptic strength in a manner consistent with ltp. Test whether saturating ltp in a specific neuronal population prevents learning dependent on those neurons. A few examples of experiments that link processes necessary for ltp to behavioral memory. There are literally 100s of studies that support the conclusion that many of the processes necessary for experimental ltp are also necessary for memory in animals.
