D103 - Lecture 15 - Signaling I.docx

3 Pages
55 Views
Unlock Document

Department
Biological Sciences
Course
BIO SCI D103
Professor
Grant Mac Gregor
Semester
Winter

Description
A. Clicker Question a. Which would be a Poor signaling molecule? i. Collagen b. Good signaling molecule i. Nitric oxide 1. Dialation of blood vessels ii. Phospholipids 1. Lipid with a phosphate on it 2. Amphipathic 3. Overs around the lipid bilayer b. Don't need a plasma membrane to enter a cell? i. Estrogen 1. Hydrophobic but also hydrophillic A. Plasma Membrane a. Selective permeability b. Insulates cell from extracellular membrane B. Yeast C. G-protein coupled receptor a. GPCR b. 3 subunits i. Alpha ii. Beta iii. Gamma b. Heterotrimeric B. GPCR a. Important role in yeast signaling b. Humans in olfactory receptors B. Achondroplasia a. Short-stature b. Single base change that affects a single amino acid in a receptor c. Developmental problem B. Retinoblastoma a. Homeostatic problem b. Tumor in the retina B. Cell signaling - Long Distances a. Glucose i. Broad response ii. Many cells respond b. Hormones c. Neurotransmitters i. Long distance signaling ii. Long axon iii. NT is released over a short distance b. Neurohormones i. Long distance B. Signaling- Short distances a. Connectones i. Made of connexins ii. Gap junctions iii. Direct cytoplasmic between cells b. Contact-dependent signaling i. Interaction between membrane molecules on the cells b. Autocrine signals i. Acts on the same cells that have secreted it ii. Negative feedback b. Paracrine Signals i. Acts on adjacent cell
More Less

Related notes for BIO SCI D103

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit