HSC 4555 Lecture Notes - Lecture 15: Smooth Muscle Tissue, Fibrous Cap, Foam Cell
Document Summary
Lot of pressure coming from the l ventricle. Core = debris, smooth muscle cell, extracellular matrix. Smooth muscle cells- intima becomes inflamed overtime the wall become permeable will migrate to core. Core becomes fibrotic makes fibrous cap which keeps everything contained (develops overtime) Plaque shouldn"t rupture if fibrous cap is stable. You don"t know you have a plaque because you live an active life. Have to be at 90% until you can feel the symptoms. Plaque is so big supply is not meeting demand. If ruptures and is unstable due to high blood pressure that pass by. The more risk factors the greater the risk. 1 pack or more of cigarettes a day = two times the risk. Rupture of plaque may travel and lodge in someplace such as lungs and cause problem. Coronary bypass: just bypassing the route of the plaque, use other veins as a different route not reversing disease just finding other routes.
