PCB 3233 Lecture Notes - Lecture 1: Antigen-Presenting Cell, Thymocyte, Mhc Class I
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Where does positive selection take place and where does negative selection take place: lifespan of a t cell, short or long compared to a b-cell, if you are heterozygous for the mhc (hla) genes how many presenting. 8: what are the reasons for the several day delay in a primary response. Infection transport to secondary lymphoid tissue antigen processing and presentation small initial # of lymphocytes specific for the antigen proliferation and differentiation: lfa-1, icam-1, l-selectin, vascular addressin. If not, when do they make it: langerhan"s cells, what and where are they, mature dendritic cells vs. immature dendritic cells. What does activation mean? (look at transcription factors that are initiated). What do they do when they come together: ctl"s recognize peptide on mhc i. Homing to where: can effector t cells be stimulated in the absence of co-stimulatory signal, ifn , cd8 t cells, activation of macrophages.
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1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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