PCB 3233 Lecture Notes - Lecture 1: Fragment Antigen-Binding, Cytidine Deaminase, Complementarity-Determining Region

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12 Apr 2016
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5) bonds; also contain various amounts of carbohydrate atachments have diferent lengths and sugar atachment in structure, no hinge region in igm or ige but have four. Heavy chain isotypes to form igg, iga, igm, ige, igd - have difering efector funcions. Igg - four subclasses; most abundant ig in blood, fc fragments bind to fc receptors on pathogens; crosses placenta to provide humoral immunity to developing and newborn infant. Igm - pentameric with j-chain in blood, otherwise it is a b cell receptor; irst anibody produced by b cells; early response eiciency due to avidity. Igd - low quaniies in circulaion and present on b cell as a receptor with igm; not much known. Hv also = cdr (complementarity determining region) there are three cdrs in each domain. Cdr 3 has the highest diversity: soma ic hypermutaion is a type of speciic point mutaion. Involves acivaion-induced cyidine deaminase (aid), which converts cyidine to uracil.

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