LIFESCI 2 Lecture Notes - Lecture 8: Gtpase, Molecular Switch, Extracellular Fluid
28 Oct 2016
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Blood glucose ability to regulate glucose levels. G-protein a molecular switch on gtp bound off gdp} built-in kinase. Heterotrimeric a, b, gamma subunits (alpha is gtpase) G-proteins are important to hormone responses, visual and other sensory reception, etc. Kinase binds and hydrolyzes atp phosphate group and adds it to a serine or threonine. This is maintained by the nervous and endocrine systems. Body cells are in contact with a liquid internal environment (extracellular fluid) and stability of this internal environment is essential for normal cell function. Maintenance of a relatively stable internal environment is termed homeostasis. The key to maintaining stability of the internal environment is the presence of regulatory mechanisms in the body. Regulatory systems have set points and respond to feedback information. Negative feedback corrects deviations from the set point (ac turning on: most biological systems use negative feedback for stability.
