MCD BIO 138 Lecture Notes - Lecture 17: Apical Ectodermal Ridge, Lateral Plate Mesoderm, Limb Bud

• School: UCLA
• Department: Molecular, Cell, and Developmental Biology
• Course: MCD BIO 138
• Professor: Lyons

Document Summary

Lec17 limb development: basic pattern of bones conserved throughout mammals, tho overall bone structure different (variation of common theme) Limb formation from limb buds: limb formed from lateral mesoderm mammals have flat embryo: Furthest edges: lateral mesoderm, most ventral mesoderm: limb bud: first morphological sign of limb development. 4 pairs for most vertebrates: 2 interacting tissues: limb lateral plate mesoderm & overlying ectoderm limb lateral plate mesoderm -- locally proliferate & give rise to limb buds. Ectoderm -- becomes signaling center (apical ectodermal ridge); helps allow local proliferation to take place reciprocal interactions: interaction between limb mesenchyme & overlying ectoderm/apical ectodermal ridge (think appendage development) limb axes: 3 main axes: Formation of limb elements: comparing chicken & mouse, look at pattern of bone formation: Proximal bones formed first, distal bones formed later