MCD BIO 165A Lecture Notes - Lecture 18: Heterochromatin, Barr Body, Lysine
12 Dec 2016
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Labelled chromosomes in diff colors: chromosomal territories. Prokaryotes do not have defined region for dna: naked dna. 3 major components: nuclear envelope, nucleoplasm, nucleolus, some cells have more than 1, site where there is a lot of ribosome generation rrna synthesis (to form ribosomal subunits) 2 membranes (inner/outer ne: direct continuation w/ er, 10 nm separation btwn the 2 membranes. Lamina: cytoskeleton/support of nucleus, made of 10 nm if lamins, 3 types of lamin - a/b/c, regulated by phosphorylation/dephosphorylation, dismantled for mitosis -> phosphorylation needed, 60 transmembrane proteins. Nuclear envelope sense mechanical forces in ec thru nesprin connection to cytoskeleton to integrins to. Premature aging - mutation in lamin/proteases that process lamin to assemble lamina. Mutations in lamin a/c -> premature aging disease. Mutation in lamin b -> loss of myelin, affects pns. 40 kd in size can pass thru pores. Npc are made of 30 nucleoporin proteins: 20 to 30 nm wide. Transmembrane ring: nucleoporins within (fg repeat domain)
