ANSC 3316 Lecture Notes - Lecture 5: Conformational Change, Camp-Dependent Pathway, Cytokine
Document Summary
The binding of hormone to receptor causes a physiological response (fourth criteria of hormone action: transmission of signal from hormone to receptor to physiological action is called signal transduction, signal transduction. In general, system is based on chemical nature of hormones; primarily based on ability of hormone to transverse cell membrane. Protein hormones cannot transverse membrane; receptors located on cell surface. Steroid hormones can transverse membrane; receptors located inside the cell: to identify hormone receptor (criteria) Must bind hormone with specificity and high affinity. Must be a finite number of receptors (saturable) Cellular location must fit action has to make sense. Binding must initiate a specific biological action typical to hormone: important terms for hormone action within a cell. Steroid hormone action: chemical nature of steroids. Within cell, cytosol, or nucleus or even attached to the genome itself. No need for external receptor or second messenger: action. More directly at dna: terms important to steroid hormone action.
