MCB 4211 Lecture Notes - Lecture 4: Lipopolysaccharide, T Cell, Congenic
6 Sep 2016
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Haptin: small molecule on its own not large enough to induce immune response, coupled with carrier protein to become immunogenic. Antigen: class of molecules recognized as foreign depending on context, specific molecular shape receptor molecule recognizes. Carrier protein 1: part of immunogen is diff from carrier protein 2 used in precipitate reaction. Antibodies react with antigens: forces that hold them together work over very short atomic distances (why shape is important, only when fit is very good will there be a reaction. Epitope prediction: being able to look at molecule and see where antigenic determinants are is possible, what shapes most likely to illicit antibody to make. Individuals have different capacities to react to same. Using congenic mice made my george snell: was able to map these genes that fell into the major histocompatibility complex. Humans- hla: immunogenicity requires appropriately responsive individual exposed. Hugh mapped immune response genes mhc class.
