MCB 2610 Lecture Notes - Lecture 10: Pyocyanin, Rifampicin, Septic Shock

• School: UConn
• Department: Molecular and Cell Biology
• Course: MCB 2610
• Professor: Patricia Rossi

Document Summary

Spore-forming - can survive for 2 yrs. Long irregular-shaped rods, single or in short chains. 2-5% have it in their intestines- kept under control by normal flora. Found everywhere in nature (soil): first isolated from infant stool by hail & o"toole in. Transferred through fecal/ oral route: can be treated with metronidiazole or vancomycin, probiotics are used to help restore the normal gut flora. 0. 6-1 micrometer, long chains of cocci: first named by rosenbach in 1884, studied by. 1930s: causes group a streptococcal infections, most frequent human pathogen. 5-15% of pop. carry it: requires enrichment medium- blood agar, causes strep throat, impertigo, scarlet fever, &deep layer cellulitis, necrotizing fasciitis, toxic shock sy: early recognition critical- gram stain, b. hemolysis on blood and catalase negative, serological id looking for presence of group a specific polysaccharide. Sensitive to penicillin: attach to host cells via pilli, mesophile- grows optimally at 37 degrees.