PHAR 1001 Lecture Notes - Lecture 3: Xenobiotic, Adipose Tissue, Membrane Transport
Document Summary
Chemicals can be categorized into 3 main types: Black: slide notes: more direct way of causing toxicity. Xenobiotic metabolites as ultimate toxicants: a lot of compounds we ingest are not toxic to begin with but when it is broken do(cid:449)(cid:374) i(cid:374)to (cid:373)eta(cid:271)olites that"s (cid:449)he(cid:374) (cid:449)e run into issues. Reactive oxygen or nitrogen species as ultimate toxicants [ros/rns: result in the production reactive o2/n2 species that cause damage. Xenobiotic = any foreign chemical we are exposed to. Step 1 delivery from the site of exposure to the. Step 2 reaction of the chemical with the target. Step 3 injury? (can be therapeutic when it comes to killing cancer cells) Step 4 repair: step 1 delivery: from the site of exposure to the. Therefore, the elimination of many chemicals depends on their metabolism to more water soluble compounds: excretion-if chemicals are water soluble, or can be metabolized to water soluble compounds, they can be eliminated in the bile or urine.
