PNB 2265 Lecture Notes - Lecture 30: Cotransporter, Collecting Duct System, Osmotic Concentration

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Use pumps to make a gradient: each pump does a 200 difference. Examples: heat exchangers, loop of henle (ascending and descending limb, loop+vasa recta. Can be artery vs vein: move from one condition to another in both places, in opposite directions. Ducks have countercurrent flow of blood in feet so they don"t get hypothermia in cold water: veins come back and pick up heat from arteries for heat exchange. In humans: flow of urine and flow of blood, ascending and descending limb are always a countercurrent. Can exchange salt between: countercurrent between each limb in the vasa recta. Serving the limb causes countercurrent: also between limbs and vasa recta** Note permeability characteristics of each segment of tubule, and follow changes in osmolarity of. It takes 2 transporters to move na from lumen blood in ascending limb epithelial cells. Nkcc2 na-k-2cl cotransporter: from lumen through apical membrane. Basolateral=blood: sodium has to go through the lumen side too.

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