PNB 2265 Lecture Notes - Lecture 24: Formaldehyde, Extracellular Fluid, Glutamine
11 Sep 2017
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Acid base balance: homeostasis of h+ in the body. Regulation of h+ in the body: buffers (immediate but temporary solution) Buffers are effective for short-term ph regulation only: reversibly bind h+ ions, can take up to correct excess or let go to correct lack of h, immediate response to altered [h+] Hco3- + h: buffers in the body, primary extracellular buffer is the co2 - hco3 system: H2co3: carbonic acid: weak acid, give up h+ or pick up as needed, intracellular buffers, phosphates, proteins (depends on structure of r side chains. *note: @ph = 7. 4, [h+] = . 00004 mmol/lit. With our high protein diets, we turn over 40 80 mmol of h+ each day underscores importance of buffers! Buffers are an instant short term response to ph imbalance. Regulation of h+ in the body: respiratory system (source of trouble or solution)
