CHEM 6AL Lecture Notes - Lecture 2: Phase Transition, Dont, Optical Rotation
Document Summary
Determine how easily we can purify a molecule. Forces of attraction that exist between molecules in a compound affects solubility. Important in solutions of ionic substances in polar solvents (nacl in h2o) Ch4 boiling point: - 162 c (lower bp b/c no hydrogen bond: h2o boiling point: 100 c, h2s boiling point: - 40c (lower bp b/c no hydrogen bond, more hydrogen bonds = higher b. p. Ch3och3 boiling point: -23 c (lower bp b/c no hydrogen bond: )mportance: vancomycin example influencing structure of proteins, considered to be dipole-dipole interactions (but stronger) Dmso: london dispersion (van der waal)/induced dipole, no attractive interactions but motion of electrons can result in (cid:498)transient dipoles(cid:499, movement of electrons in the molecule generate temporary (+)/(-) regions in the molecule. Ex: acetone dissolves nai, acetic acid, benzene, & hexane. Avoid contact with organic solvents as much as possible. Excessive exposure = carcinogenic, toxic, flammable (except chlorinated solvents)
