BILD 2 Lecture Notes - Lecture 4: Pylorus, Gastric Acid, Peptic Ulcer

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Digestive system, alimentary canal - mouth to anus, mouth, teeth: mechanical breakdown. Starch amylase -> maltose (disaccharide: stomach, muscular sac at end of esophagus, mechanical breakdown - peristaltic contraction - muscle contraction in a wave. Smooth muscles: chemical breakdown - 3 secretory cell types in stomach wall -> gastric juices, type 1 parietal cells. Secrete h: hcl 0. 1m h+ >>> ph = 1, acidic ph, activates enzymes, defense against invaders. Secrete pepsinogen: pepsinogen @ low ph --turns into--> pepsin & polypeptide, pepsin -> partial breakdown of proteins (inactive enzyme) (becomes active at acidic ph, type 3 mucus cells. Inactive enzymes secreted into small intestine: activated by enterokinase (enteropeptidase) Starch ---amylase--> maltose ---maltase--> glucose: monosaccharide disaccharide monosaccharide, dna/rna ---nuclease--> nucleotides. Fat ---lipase--> fatty acid & glycerol: fat digestion. Liver secretes bile: gallbladder has bile concentrated 10x, also excretes bile, bile salts >> fat absorption emulsifies fat into droplets (micelles) like hand soap, emulsified fat ---lipase--> glycerol & fatty acids.

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