PSYC 181 Lecture Notes - Lecture 19: Hypoventilation, Solitary Tract, Knockout Mouse
Document Summary
Opioid receptors: subtype: mu; preferred ligand: morphine and endorphins, subtype: delta; preferred ligand: enkephalins, subtype: kappa; preferred ligand: ketocyclazocine and dynorphins. Inhibit the intensity of the pain and the signal overall: supraspinal actions. Specific blockade of 1 shifts dose-response curve for morphine analgesia up to. 12 fold to right that means the morphine is less effective: heroin vs. morphine. Pharmacokinetics: adding acetyl groups to morphine makes it more lipid soluble, so heroin gets to the brain more quickly recent evidence for different receptors: Experiment: mor-1 knockouts: morphine, but not heroin, have analgesia abolished in mor1 knockout mice reinforcing effects, all classical opioid drugs of abuse have a preference for sites (morphine, heroin, methadone, fentanyl) (cid:373)a(cid:374)y contribute, but little known: k compounds are not self-administered. Psychomimetic and aversive in humans: opioid/da interaction. Da antagonist or 6-ohda lesion impair sa. Da antagonist into vta or acc impair sa: mechanism. Compounds: increase da cell firing increase da release in acc.
