NTDT401 Lecture Notes - Lecture 5: Cardiovascular Disease, Pylorus, Methylmalonyl-Coa
20 Dec 2016
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5 methyl convert to thf (without methyl) Converts homocysteine to methionine and then convert to sam. B12 comes from only animal food (vegans lack b12) Importance of b12 is how we can use it; Very large; hard to make- get from animal food. Colbalt in the middle with 6 bonds (colbalt has no other functions; is only part of b12) 4 colbalt bonds linked to nitrogen; 2 bonds can link to cysteine, methyl, water and adenosine (varies) Is a problem in all countries, not just in poor countries multiple coenzymes: 5-methyl involved in methyl-folate-homocysteine reaction, involved in converting propinyl coa to succinyl coa. Animal products (derive their cobalamin from microorganisms; the yeast of bacteria: meat, poulty, fish, shellfish, eggs, milk, milk products. Ingested cobalamins must be released from food matrix. Large vitamer: attached to polypeptides (proteins) in foods, release occurs via action of pepsin (stomach/pancreas acids) Released cobalamin interacts with 2 proteins: r protein (in saliva and gastric juice)
