FNN 200 Lecture Notes - Lecture 6: Aminopterin, Adipose Tissue, Hematocrit

• School: Ryerson University
• Department: Nutrition and Food
• Course: FNN 200
• Professor: Hartman

Document Summary

Sources of b12: b12 or colbalamin produced by microorganisms, animal products & meat alternatives, well balanced diet = 5 15 mg/d, requirements (cid:224) rda 2. 4 g/d adults(cid:224) 2. 8 g/d during pregnancy. 1. 5 2mg: passive diffusion above this ~1 3% absorption, absorption on receptor sites in ileum(cid:224) cubilin (intrinsic f cobalamin receptor, transportation of vitamin b12(cid:224) trans cobalamin ii, storage of vitamin b12, most of b12 stored in liver, doxyadenosyl cobalamin, hydroxycobalamin, methylcobalamine. 3: disease states(cid:224) celiac, crohns, gerd, gastric bypass, age, social(cid:224) religion, food insecurity, ses, dietary (cid:224) vegetarian/vegan, barriers to animal foods, dysphasia, physical issues in eating, lifestyle (cid:224) obesity, chronic alcohol abuse. Peripheral and cns damage: posterior column > loss of vibration and position sense, sensory ataxia, lateral column, limb weakness, spasticity, extensor/plantar reflexes, cerebral, mild depression, memory loss, psychosis. Assessment for b12: serum b12 + smear, hyper segmented neutrophils, holo transcobalamin, methyl malonic acid (mma, schilling test *, plasma /serum total homocysteine.