PSYC414 Lecture Notes - Lecture 4: Lipid Bilayer, Agonist, Methyl Group
15 Feb 2018
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Too much drug receptor floods maintain homeostasis down regulation. Cross section of typical capillaries and brain capillaries. To get drugs into brain lipid soluble: transport mechanisms, sodiu(cid:373), potassiu(cid:373), (cid:272)hloride, (cid:272)al(cid:272)iu(cid:373): (cid:449)o(cid:374)(cid:859)t go through lipid (cid:373)e(cid:373)(cid:271)ra(cid:374)e. Has to be charged; transform drug in the liver. Fat soluble drugs get into target tissue. Water soluble & fat soluble drugs in blood. Goes to kidney: charged particles get trapped, fat soluble goes through the membrane and get back out into the blood stream. Once in the blood stream, goes to different organs; in the liver, enzymes take chemicals to change them. It is now a water soluble metabolite of the drug; once in the kidney, it gets trapped and collected in the urine i. e. , methyl group (ch3) Enzyme 1a2 removes the methyl group from the drug; chemical is now charged. Demethylation process: less fat and more water soluble. Enzymes work in particular ways; concentration dependent manner.
