PSYC414 Lecture 19: Schizophrenia
10 May 2018
School
Department
Course
Professor
5/10
Final exam
1. ** everyone answers = addiction
a. older views of addiction (physical dependence) new ones (relapse) compare
and contrast mechanisms of physical dependence (withdrawal) and addiction
(relapse)
b. processes/mechanisms of learning, memory, and plasticity in relation to
addiction; neural circuits (mesolimbic, cortical, PFC circuit, AMG)
c. NT and anatomical systems important for these symptoms
i. i.e., DA
2. Schizophrenia
a. Neurobiology, anatomy, genetics, environmental/developmental aspects,
chemistry, etc.
b. Mechanisms of the drugs
3. Antidepressants
a. Partially effective, delayed effectiveness
b. How do they work
c. Why do they take so long to become effective
d. New drugs may shorten the effects (i.e., ketamine)
4. Pain/ morphine
a. Pathways of pain, how morphine alleviates pain
b. How does tolerance have an effect; why do we have certain withdrawal
symptoms that we do
c. Consequences of taking morphine too long – tolerance/withdrawal
Schizophrenia
❖ Hallucinations (mostly auditory)
❖ Delusions / paranoia
❖ Lack of interest
❖ Hearing voices
❖ Disoriented speech
❖ Social cues
❖ Manic component / restlessness
❖ Anxiety/depression
❖ Repeated behaviors/stereotypies; nervous energy
late adolescent/early 20s
Positive symptoms delusions, hallucinations, disordered speech, bizarre behavior
Negative symptoms alogia (reduced speech), flattened affect, avolition, social withdrawal,
anhedonia, intellectual impairment
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