BIOL 3305 Lecture Notes - Lecture 5: Atp Synthase, Thermogenin, Allosteric Regulation

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6 Aug 2018
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In the presence of ucp 1, protons pumped out into mitochondrial space. Atp production. (cid:131) poke holes in inner mitochondrial membrane, do it chemically, dinitrophenoyl: could check ph, electron transfer generate electrochemical gradient. (cid:131) If they are readily available atp is in short supply, they act as allosteric regulators. (cid:120) the products of these reactions can allosterically inhibit these rates. Acetyl-coa can allosterically inhibit glycolysis: hibernation and torpor (cid:131) when animals encounter low food/temperatures, enter these states. (cid:131) model that was used is the ground squirrel, good hibernators, substrate oxidation, adp phosphorylation, proton leak (cid:131) They need this because there body is at 5 c, need fluid membranes. (cid:120) If they have excess pufa"s almost as bad as not having any at all. Excess will cause them to not enter hibernation properly: suppression of mitochondrial respiration contributes to lowering of metabolic costs during hibernation and torpor.

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