MCB 150 Lecture Notes - Lecture 29: Endosome, Mannose, Phospholipid

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Published on 5 Apr 2017
School
University of Illinois
Department
Molecular and Cell Biology
Course
MCB 150
Professor
Lysosomes, or “What happens when the cell needs to degrade something?”
Announcements
Exam 3
April 13
Review session monday 5-7
Material will be through Monday’s lecture
No office hours today
Lysosomes
Lysosome is the toolbox, lysosomal acid hydrolases are the tools.
These hydrolases only are found in the lysosome and they are only active
in environment of pH of around 5
We do this to protect ourselves so that the hydrolases will not hurt
the cell if the lysosome explodes
Multiple types of each
Proteases and peptidases
Nucleases
Glycosidases
Lipases
Phosphhatases
Sulfatases
Learning catalytics
Why does a lysosome not degrade itself? Choose all that apply.
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Document Summary

Lysosomes, or what happens when the cell needs to degrade something? . Lysosome is the toolbox, lysosomal acid hydrolases are the tools. These hydrolases only are found in the lysosome and they are only active in environment of ph of around 5. We do this to protect ourselves so that the hydrolases will not hurt the cell if the lysosome explodes. The lumenal surface of a lysosomal membrane contains a thick layer of carbohydrate (this part is true), and there are no enzymes in a lysosome that hydrolyze carbohydrates (this part is false). The membrane of a lysosome is synthesized with special phospholipids that are more resistant to hydrolysis. There is no special lipid resistant to hydrolysis. Mannose-6-phosphate provides a special signal that prevents acid hydrolases from catalyzing their respective reactions in the presence of that signal. Mannose -6-phosphate is only a zip code. Only tells where to take the proteins.

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