BIOS 230 Lecture Notes - Lecture 1: Hiv, Zidovudine, Integrase
Document Summary
Summary 1 2016 hiv evolution and drug resistance: hiv and the study of evolution. From the point of view of an evolutionary biologist. Hiv is a useful model for studying evolutionary processes. From the point of view of a health care / disease researcher: Much of what we know about hiv has come from studying the evolutionary processes that affect. -drug resistance involves the process of natural selection. -smart treatment and drug design requires an understanding of natural selection and molecular evolution. -patterns of hiv transmission can be followed using principles of population genetics and phylogenetics. -the source of hiv from non-humans was discovered through studies of phylogenetics. We will talk about the first two of these today, and the others later in the semester: natural selection and hiv resistance to azidothymidine (azt) Hiv life cycle - figure 1. 5: free virus particles, virus attaches to proteins on cell, virus fuses to cell.
