BIOLCHEM 415 Lecture 34: Lecture34_Chapter37_Apr8_Vojtek_2016
Document Summary
Gene expression in eukaryotes: rna polymerases in eukaryotes, regulation of rna polymerase ii, regulation of gene expression by hormones, chromatin remodeling and gene expression. Gene: a region of dna that is transcribed to produce a functional. Rna molecule: the rna molecule may encode a protein (messenger rna) Rna processing, including extensive processing of mrna precursors. The nuclear membrane, which separates the site of rna synthesis from that of protein synthesis. Eukaryotes physically separate rna & protein synthesis mrna is translated while it is being transcribed: transcription and most rna processing occurs in the nucleus, mrnas are exported to the cytoplasm, where translation into protein occurs. Amanitin: rna polymerase poison: produced by the poisonous mushroom amanita phalloides (aka the death cap or the destroying angel, binds near the active site of rna polymerase and prevents the translocation along the dna. Eukaryotic rna polymerases are related to prokaryotic rna polymerase and use an identical catalytic mechanism.