BIOLCHEM 415 Lecture Notes - Lecture 19: Cardiac Muscle, Oxaloacetic Acid, Thiamine Pyrophosphate

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Recall in glycolysis that there are two pyruvate molecules that are formed. The enzyme responsible for oxidizing pyruvate is the pyruvate dehydrogenase (pdh) complex. There are large number of cofactors that are used by this complex and many of them are essential vitamins. We will talk about the regulation of this complex. Recall in glycolysis, one molecule of glucose (6-carbon sugar) goes through a series of reactions to make 2 molecules of pyruvate (3-carbon sugar) We will focus on how pyruvate in the process of aerobic respiration can be converted to atp. The first step requires the pdh complex which oxidizes pyruvate to acetyl coa forming carbon dioxide and 2 electrons that are captured by a cofactor. This acetyl coa then enters the citric acid cycle (will be covered in the lecture on. So the pdh functions as a bridge between glycolysis and the citric acid cycle. This enzyme functions in the matrix of the mitochondria.

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