EEB 390 Lecture Notes - Lecture 2: Synonymous Substitution, Probability Distribution, Protein Structure
9 Oct 2020
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Neutral mutations: have little or no effect on an organism"s tness. Unlikely that any mutation is truly neutral (no effect at on tness at all) All mutations have some effect, but can be categorized as neutral when the effect is undetectably small. According to the nearly neutral theory: most mutations are neutral or nearly neutral. Advantageous mutations: increase tness by allowing organisms to adapt to their environment. Relatively few mutations that are not effectively neutral are advantageous. Deleterious mutations: harmful to the tness of an organism. In reality, a continuum of effects exists, from strongly deleterious to highly adaptive. Paper 1: synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory. tomoko ohta. Chosen for large regions, this minimizes a change in function over time. Change in the sequence that codes for amino acids in a protein, but does not change the originally intended amino acid.
