EEB 390 Lecture 5: eeb lect 5

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Variation: within squirrels there are darker and lighter coats, even albino. Alleles for brown and black coat colors (we are going to use a1 and a2: brown = a or a1, black = a or a2, genotypes: aa, aa, and aa, a1a1, a1a2, a2a2. Why are populations di erent: we don"t see mendelian ratios in populations, recessive (and even those without selective advantage) can remain in populations, cystic brosis. Is can stay in population without selective advantage. Question: over time, what will be the frequency of alleles and genotypes? and can we describe this mathematically: we have one trait one locus (location on the chromosome) that is encoded by two alleles. Pretty unrealistic: assumptions of hardy weinberg, no natural selection, no mate preference, no mutation, no migration, population size is in nite. Null hypothesis: hardy-weinberg is a null hypothesis for population genetics, we can calculate what alleles and genotypes would be (expected) if the assumptions of hardy-

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