PHYSIOL 201 Lecture Notes - Lecture 27: Respiratory Acidosis, Alkalosis, Metabolic Acidosis
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Lecture 27: renal regulation of ph and ca+2. When ph starts to change, proteins change their shape. If the shape changes, the function will be affected. Normal ph is 7. 4 (same as arterial blood) Eliminating h+ from the kidney is normal to maintain normal ph. Lungs control co2 which is an acid and this is how they control ph. When there is more co2, it drives the reaction to the right and vice versa. The changes can be instantaneous because it is neural inputs. The co2-bicarbonate is one of our buffer system. We also have proteins which hydrogen ion can bind to and change its conformation but also serves to maintain ph. The major intracellular buffer are the proteins inside the cell and the phosphate. If hydrogen ion concentration is increasing a lot, then even with buffers ph is changing (just changes less compared to if you had no buffers at all)
