BIOLOGY 151 Lecture Notes - Lecture 4: Ubiquitin, Signal Transduction, Proteasome
Document Summary
Tk2 activates a phosphatase that targets tk1 false. Tfa activates a gene that encodes a phosphatase that targets tfa. Tfa activates a gene that encodes a phosphatase that targets tk2 true. Without a phosphatase it will remain phosphorylated. When a kinase and a phosphatase both target the same protein the ubiquitin - dependent proteolysis. Ubiquitin is selectively attached to proteins destined for destruction. Ubiquitinated proteins are moved to the proteasome and destroyed. Gene expression produces proteins that populate the cytoplasm. Even before the signal appears, gene encoding receptor, tk1, tk2, tfa are on. We know that because all of those proteins are present in the cell. Kinase and phosphatase activity regulate protein function. Ubiquitin- dependent proteolysis causes the destruction of specific proteins. Activated proteins get destroyed and no new ones are made. Activated proteins get destroyed and new ones are made.
