BIOLOGY 151 Lecture Notes - Lecture 7: Maturation Promoting Factor, Interphase, Mitosis
21 Dec 2015
School
Department
Course
Professor
Document Summary
Bio151 lecture 7 control mechanisms of cells. An experiment: a small amount of cytoplasm is removed from a cell in mitosis and added to a cell in interphase. That is if you took cytoplasm from cell 2 and injected it into cell 1 would the cell go back to interphase: no, because it is like a clock: you cannot go back in time. The factors that lead to this effect was called mpf (first it was maturation promoting factor, then mitosis promoting factor). Cyclin / cyclin-dependent kinase (cdk) component of the bound to cyclin targets the complex. Cdks are a major cell-cycle control system. Cdk/cyclins controls which phase of the cell cycle is occurring. A cdk/cyclin phosphorylates rb inactivating it at the start checkpoint. As shown in the diagram to the right, the cdk / cyclin complex causes rb to phosphorylate and leads to the release of e2f from the rb. Cdk and cyclin have different names in every organism.
