BIOLOGY 152 Lecture Notes - Lecture 7: Voltage-Gated Potassium Channel, Tetraodontidae, Tetrodotoxin
Document Summary
Bio152 lecture 7 action potentials and applications. Voltage-gated ion channels: na+ a fast opening gate a slow closing gate, k+ a slow opening gate. Voltage-gated ion channels and diffusion: remember: there are negatively charged macromolecules that cannot move in, once the channel opens, ions follow chemical and electrical gradients and out. Stages of action potential: resting state, threshold, depolarization phase of action potential, repolarization phase of action potential, undershoot, back to resting state. In the liver of the puffer fish, and throughout it"s tissues, has a toxin called tetrodotoxin. Tetrodotoxin immunity: small random changes to the shape of ion channel keep toxin from blocking the channel. Individuals with changed ion channels have a higher probability of surviving and pass that change on: oddly, the same changes occur in a diverse and evolutionarily distant related groups of animals, evolution can repeat itself!