MICROBIO 140P Lecture Notes - Lecture 23: Complementary Dna, Chemotherapy, Lead Compound
23 Apr 2016
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Inhibit folic acid synthesis o: broad spectrum. Types of antibiotic (based on their mode of action: bacteriostatic antibiotics stop bacteria from proliferating, bactericidal antibiotics kill bacteria cells (still need the immune system, antibiotics need the immune system in order for them to work. This is why people with hiv eventually end up dying from infection or disease because the antibiotics can"t kill off the illness without the help of antibodies. Sulfonamides: developed: 1930s, resistance observed: 1940s. Penicillin: developed: 1943, resistance observed: 1946. Bacteria evolve to stop the above process. Bacteria (asexual) use horizontal transfer to reproduce o. Through horizontal transfer they evolve to stop penicillin from working. Every time we develop a drug, the parasites become resistant. The use of antibiotics directly leads to drug resistance. Up to 50% of all prescribed antibiotics aren"t needed or aren"t optimally effective as prescribed wasn"t completely eradicated. Tb is becoming one of the three big diseases in the world because it.
