MICROBIO 160 Lecture Notes - Lecture 16: Test Screening, Cervarix, Herd Immunity

• School: UMASS-Amherst
• Department: Microbiology
• Course: MICROBIO 160
• Professor: Mitchell Walkowicz

Document Summary

Biology of cancer and aids 10/26/15: viral infection and cancer. Cervical cancer is a major killer throughout developing world, particularly. Africa: rare in developed countries because almost always preventable through regular pap smears, cervical cancer is responsible for about 12,000 new cases and 3,600 deaths each year in the us. Incidence and mortality: estimated new cases and deaths from cervical cancer in the us in. Risk factors: hpv infection (human papillomavirus, multiple sex partners (high risk male partner, started having sex before age 18, other stis (hiv, syphilis, chlamydia) Low socioeconomic status: molecular genetic factors: p53, rb mutations. Currently there are over 100 identified types of hpv, roughly 40 of which cause mucosal infection. There are 18 different types of high-risk hpv which can be oncogenic. Prevalence and consequence of hpv infection and cervical cancer cases worldwide. 10 million new cases of high-grade cervical dysplasia. 30 million new cases of low-grade cervical dysplasia.