NUTRITN 230 Lecture Notes - Lecture 5: Hepatotoxicity, Paracetamol, Atherosclerosis
23 Mar 2016
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Document Summary
Ethanol is readily absorbed from gi tract and is transported unaltered in the bloodstream. May be up to 12% of energy intake in nonalcoholic and up to 50% in alcoholics (4 ounces of wine = 12g. More than 90% of ingested etoh is metabolized. A healthy person can usually metabolize 5-7 grams of ethanol each hour. Etoh is metabolized by 2 main enzyme systems: alcohol dehydrogenase (adh) pathway o o o o o o o o o o o o o o o. Adh is in cytoplasm (liver) and requires zn and nad+ (h acceptor) Oxidizes etoh when it is present in low-moderate concentrations. With chronic, higher intake, other enzyme systems become involved. Nadh can be oxidized for atp in electron transport system. Attaches to proteins and alters function and structure causing cirrhosis in the liver. Some ethnicities (asians) have special forms of adh that promote rapid production of acetaldehyde.
