BIOL 208 Lecture Notes - Lecture 4: Intrinsic Factor, Capillary, Macrocytic Anemia

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Megaloblastic- rbcs vitamin b12 deficiency or folic deficiency. Vitamin b12 - if deficient- cell begin to slow down. Not due to lack of vitamin b12, due to lack of protection. Pyloric region- region of stomach produces intrinsic factor. When vitami b12 goes through stomach, intrinsic factor attaches and prtects vitamin b12. Autoimmune response - cells in pyloric region destroyed- leads to poor vitamin b12 absorption. If number of blood lost is less than 1 liter, interstitial fluids (b/w cells) body can compensate - causes anemia. If lost more blood = need for transfusion. Bone marow destoyed - no more blood cells and formed element. Bacterial toxins can destroy red bone marrow. Changing 1 amino acid in alpha chain. Cause rbcs to be pulled into shape. Part or whole blood cell can be missing. Usually only 2 million rbcs per cubic millimeter. Ex. p. vera - result of bone marrow cancer and hematocrit doubles.

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