BIOL 208 Lecture Notes - Lecture 10: Hemolytic Disease Of The Newborn, Nephron, Rh Blood Group System
19 May 2018
School
Department
Course
Professor
Anatomy 2
Lecture 10
2/22/2018
- Blood clumping - agglutination
- Dangers of agglutination
- Blood cells begin to clump and large antibodies get stuck
- Little O2 gets into areas
- Rise to hemolysis - hemolysis releases hemoglobin
- Hemoglobin can’t pick up O2 effectively
- Clog kidney tubules - leads to kidney failure
- Homologous - pooled blood
- Autologous transfusion
- Take blood 4 or 5 weeks before surgery and supply own transfusion
- Store and cool blood to 39%
- RH factor
- Rh negative
- Not on cell surface
- Rh positive
- On cell surface
- 85% of population is Rh positive
1) 1st time - can transfuse same Rh factor
2) 2nd time - need to transfuse same blood as myself to avoid problems
- Rogam
- Fake antibody
- Injected in mom 72 hours after birth
- Covers antigens so mom’s body doesn’t discover “enemy” antigen
- Hemolytic disease of newborn
- Erythroblastosis fetalis
- Happens if mother has a reaction to rh blood
- Three lines of defensins
- 1st line of defensins
- 2nd line of defensins
- A. phagocytes
- Interferon activates macrophages, Cytotoxic T cells and NK cells
