BIOC 3110 Lecture Notes - Lecture 41: Transferrin Receptor, Ferritin, Transferrin

• School: University of Iowa
• Department: Biochemistry
• Course: BIOC 3110
• Professor: marcwold

Document Summary

Lecture 41: mechanism of protein synthesis recombinant dna techniques. Transferrin-ferritin receptor system as an example of protein translation regulation. On the mrna that codes for all three of these substances exists won"t be harmful an (cid:498)iron response element(cid:499) (cid:523)cis-acting factor) The controller of this sequence is the trans-acting (cid:498))re-binding protein(cid:499) which binds the mrna in absence of iron, to block the. Ferritin mrna has stem-loop structure at 5" end of coding region, called (cid:498)iron response element(cid:499) Since ferritin has )res on 5" end, if )re-bp is bound, it. Transferrin-receptor control- opposite of ferritin production of these iron collecting proteins. If you already have high levels of iron within cell, and continue to get more, you do not want this on. Too much iron in cell, cell will down-regulate: conditions: Low iron conditions: region of coding sequence bound, it does not block translation production of the transferrin-receptor by not protecting the mrna from nucleases, and letting it degrade.