CHEM 451 Lecture Notes - Lecture 19: Energy Landscape, P53
Document Summary
Energy landscape that we talked about in globular proteins. Disordered proteins with different features, they don"t form stable tertiary/ secondary structures. Unfolded globular proteins, top of energy funnel where there is low energy states but not lower than any other -> diffusion over barriers is accessible. Instead of existing in single state, it exists in ___ transiently populated. Interacting with binding partners stabilises protein configuration and it"s different for different binding partners. 3 diff binding partners alters landscape a little bit. Bind to binding partner, fold to canonical secondary structure. Polyq tract in whi3 = ___ doesn"t involve secondary structure formation. Idp in regions where there are protein interaction hubs. Requirerments of signalling = lots of portien that interact with each other in a time scale. Havep roteins coming tgt to signal donwstream response, dn"t want to keep signalling htat there are ___ Tend to bind with high specificity and low affinity.
