BPS 305 Lecture 5: exam 1 study guide
12 Sep 2016
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Receptors (nmda, 5-ht, beta adrenergic, opiod, etc. ) We are made of primarily aqueous media compartmented by lipid membranes. Drug molecules need sufficient solubility in membranes and physiologic media. A few drugs or prodrugs may be transported or assisted across membranes but others use transcellular or paracellular entry. Passive, transcellular diffusion across membranes and through tissues is the most important way for drugs to enter the body and get to their site of action. There is some paracellular entry between loose cell junctions, through aqueous pores (nasal mucosa), or temporarily disrupted tissues (sonication, enhancers, inflamed sites) Target drug delivery, and get it to its site of action quickly and perhaps exclusively. One of the simplest dosage forms for solid drug materials. Even oily and liquid drugs can be absorbed onto or otherwise formulated with solid excipients, and then used as powders or particulates. Versatile: topical, intransal, pulmonary, reconstitutable for parenteral, oral.
