BME 410 Lecture Notes - Lecture 20: Spin Coating, Drug Development, Epithelium
20 Apr 2016
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Drug development (cid:2) solution?? (cid:2) (cid:2) (cid:2) (cid:2) (cid:2) Drug discovery 10,000 compunds preclinical 250 (6. 5+ years) clinical trials 5 (6+ years) 1 fda approved drug. Target: includes nervous tissue, epithelial tissue, connective tissue, muscular tissue. All this leads to drug development being a huge problem. Clinical trial gone wrong: placebo has higher survival rate than on drug. Engineered, micro-scale mimics of healthy and diseased human tissues. Tissue level: tissues consist of similar types of cells. Organ level: organs are made up of different ypes of tissues. Organ system level: organ systems consist of different organs that work together closely. Epithelial and endothelial cells let carbon dioxide out while letting oxygen in in order to oxygenate the blood cells in the capillary. o: this happens in the alveoli in the lungs. Silanized pdms spin coated pdms uncured placed onto silicon master . Compression creates porous pdms membrane with silanized pdms. Teflon master; pdms mold and cerex frame.
