PHRM 201 Lecture Notes - Lecture 17: Insulin Glargine, Diabetes Mellitus Type 1, Glibenclamide
28 Oct 2017
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A 9-year-old obese male patient presents to his family physician with symptoms of fatigue, excessive thirst, and excessive nocturnal urination. He has no fever, has not been vomiting, and not had any significant change in activity or diet before the symptoms arose. What is the first test you would perform on this patient to diagnose his symptoms: no test, he"s too young and probably just exercised too much, blood and urine glucose, thyroid hormone levels, pancreatic ultrasound. Answer: b (after initial testing, the longer-term level of glucose can be estimated using glycated hemoglobin levels (hba1c, three-month average plasma glucose concentration). 30 mmol/mol normal, >50 (or 6. 5%) is diabetes. If his diagnosis is type 1 diabetes, which of the following treatment regimens would be most beneficial: an insulin secretagogue like glyburide (increases secretion of insulin, insulin injections, careful diet to reduce glycemic index, insulin and glyburide. Answer: b (type 1 diabetes is confirmed by measuring autoimmune markers for islet cell antibodies)
