GENETICS 565 Lecture Notes - Lecture 3: Panmixia, Geometric Distribution, Exponential Distribution
Document Summary
September 15, 2016 effective population size and the coalescent. Census population size: total number of individuals in an area, relevant for ecological studies. Ne(inb) = (1 ft) / 2(ft+1 ft: variance effective population size: relates the change in allele frequency variance to population size and the rate of drift. Ne(var) = pt(1 pt) / 2v(pt+1) Ne can be modified to account for departures from the wright-fisher model: variation in the number of offspring, separate sexes and variation in the breeding sex ratio, inbreeding, age structure, temporal variation in population size. Connect changes in allele and genotype frequencies over time to evolutionary forces. Keep track of all individuals in the population. Computationally expensive, and many individuals during the simulations are irrelevant to the variation at the end (since not all individuals will have the gene of interest, and many individuals during the simulation will not breed: coalescent models. Connect variation in a sample of individuals to evolutionary processes through genealogical history.
