NUTR SCI 132 Lecture Notes - Lecture 24: Megaloblastic Anemia, Pernicious Anemia, Vitamin B6
4 Apr 2016
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Oxidative damage cell membranes, cell proteins, ldl >atherosclerosis, eye- macula, degeneration cataracts. Vitamin c: extracellular fluid works in water, lungs. Vitamin e: protects lipid works in lipid. Vitamin a (retinol: carotenoids (beta carotene) >made into retinol, lycopene, intern, protect lipid. Monday, april 4, y: vision-colors, night vision, defieicency > night blindness or complete blindness (severe) Pro oxidants increase oxidative damage: in excess iron, b-carotene, balance-more is not better. Red blood cell synthesis (erythropoiesis: red blood cells contain hemoglobin which transports oxygen into cells and carry. Folate (folic acid: need for dna synthesis, cell division, macrocytic and megaloblastic anemia. Vitamin b-12 (cobalamin: folate and vitamin b-12 activate each other deficiency of one causes deficiency of another. Vitamin b-6 (pyridoxine: synthesis of hemoglobin. Iron more common deficiency: most common anemia, microcytic anemia small cells, pro-oxidant in large amounts, storage protein ferritin backup supply, transport protein-transferrin, most common toxicity. Iron storage: anemia deplete reserves, good status=adequate hemoglobin and ferritin.
