BCHM 3114 Lecture Notes - Lecture 11: Atp Synthase, Intermembrane Space, Oxidative Phosphorylation

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5 Nov 2018

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Delta = change in membrane potential (mv) F = faraday"s constant (96. 5 kj/ mol * v: identify the locations of the f0 and f1 complexes of atp synthase in the mitochondrion. The proton from the ims comes through alpha complex and binds a proton to the c- subunit and the c-subunit rotates so it moves away from the alpha subunit. Bchm 3114: atp synthase, oxidative phosphorylation, and uncoupling: describe the mechanism by which the c-ring and y-subunit drives the conformational change in the beta-subunit. the b unit (not beta) holds the f1 complex in place. The alpha, and beta structures are part of the f1. The alpha structure is just structural support and is complex. Only the beta subunit synthesizes atp not catalytic. The y subunit interacts asymmetrically with the three pairs of alpha and beta units. As the y subunit rotates the alpha-beta pairs change their conformations. The y subunit rotates in steps of 120o.

Related Questions

ATP synthase can easily be said to be one of the most important enzymes in all of nature -- since without it we would have much less ability to make ATP -- and therefore much less ability to sustain energy-requiring reactions and processes.

Which of the following is TRUE about ATP synthase?

A. This is an integral membrane protein, in the inner mitochondrial membrane.

B. ATP synthesis by ATP synthase is driven by movement of protons through the protein, from the intermembrane space into the matrix.

C. Proton flow through the enzyme involves the "c ring."

D. ATP synthesized by ATP synthase is released into the mitochondrial matrix.

E. All of the above are true.

1. Compared to the generation of ATP by oxidative phosphorylation, what is a major difference in mechanism of ATP generation by substrate-level phosphorylation in glycolysis?

A. A proton gradient is not involved

B. The ATP produced has less energy content because oxygen was not involved.

C. Substrate level phosphorylation occurs in the inter-mitochondrial space

D. One can't generalize without knowing the substrate.

2. Which of the following statements is true?

A. Because the electrons in NADH are at a higher energy than the electrons in reduced ubiquinone, the NADH dehydrogenase complex can pump more protons than can the cytochrome b-c1 complex.

B.The pH in the mitochondrial matrix is higher than the pH in the intermembrane space.

C. The proton concentration gradient and the membrane potential across the inner mitochondrial membrane tend to work against each other in driving protons from the intermembrane space into the matrix.

D. The difference in proton concentration across the inner mitochondrial membrane has a much larger effect than the membrane potential on the total proton-motive force.

Please help me to understand each boulley point with explanation

BCHM 3114 Lecture Notes - Lecture 11: Atp Synthase, Intermembrane Space, Oxidative Phosphorylation

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