BIOL 1105 Lecture Notes - Lecture 10: Hypertension, Urethra, Aquaporin

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burgundycrocodile577

25 Sep 2016

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Order function: (3) ureter:c, (1) kidney:a, (5) urethra:d, (4) urinary bladder: b, (2) renal artery: e (#6-11 worth 0. 1 pt each) Bowman"s capsule, proximal convoluted tubule, ascending loop of henle, filtration, secretion, reabsorption, water, salt. To start off, molecules enter the urine by filtration out of the glomerulus and by secretion into the tubules from surrounding capillaries. Molecules that enter the filtrate can be returned to the blood by reabsorption from the tubules into surrounding capillaries. Once the blood is filtered it enters the bowman"s capsule. After the filtrate enters bowmans capsule, and it goes into the portion of the nephron called the proximal convoluted tubule. The fluid then moves through the loop of henle. While in the loop of henle, water travels through the ascending loop of henle where salt is actively transported out of the tubule and in the descending loop of henle, so water moves out, caused by osmosis.

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RENAL PHYSIOLOGY AND HOMEOSTASIS

Questions/Analysis

Part A.

1. Explain the process of urine moving out of the dialysis tubing (blood) into the cup. How does this relate to blood dialysis of patients with kidney disease?

Part B.

1. Summarize, briefly, the significance of the following parameter measured.

Color -

Nitrate -

Urobilinogen -

Protein -

pH -

Blood -

Specific Gravity -

Ketone -

Bilirubin -

Glucose -

Part C.

Parameter	Describe this parameter or measurement	Should or should not be present in urine?	Abnormal values could indicate what?
Nitrate	Usually produced by bacteria that are present and causing infection	No	A positive test could be indicative of infection
Urobilinogen
Protein
pH
Blood
Specific Gravity
Ketone
Bilirubin
Glucose

1. What potential treatment groups could cause an increase in ADH secretion? Explain why.

2. What potential treatment groups could cause a decrease in aldosterone secretion? Why?

3. What is the impact of blood pressure on kidney function?

4. Illustrate the kidneyâs handling of water and salt loads? Explain.

5. What are potential sources of error in these experiments?

6. The loss of water during sweating on a hot day causes the blood volume to decrease and the osmolarity of body fluids to increase. Outline the mechanisms operating to restore homeostasis via the release of ADH in this situation.

7. Why would prolonged elevations of blood aldosterone produce hypertension?

8. Explain, physiologically, why a person urinates more after a night of beer consumption.

sapphirelocust154

1) A drop of urine would follow this path

a) renal pyramid/major calyx/minor calyx/renal pelvis/ureter

b) minor calyx/major calyx/renal pyramid/renal pelvis/ureter

c) renal pelvis/minor calyx/major calyx/renal pyramid/ureter

d) renal pyramid/minor calyx/major calyx/renal pelvis/ureter

2) The production of filtrate starts at

a) Loop of Henle

b) capsular space

c) distal convoluted tubule

d) proximal convoluted tubule

3) Major reabsorption of water happens by ____at the _____

a) contransport, distal convoluted tubules

b) Cl- shift, nephron loop

c) countercurrent, nephron loop

d) countercurrent, ureter

4) Angiotensin II causes production of ____to increase Na + reabsorption in the _________

a) renin; collecting duct

b) aldosterone; PCT

c) ADH; nephron loop

d) aldosterone; collecting duct

5) Most of the reabsorbed compounds from the filtrate end up in the

a) peritubular capillary

b) urine

c) nephron loop

d) DCT

6) Reabsorption of urea happens by

a) transcellular movement

b) by paracellular movement

c) by cotransport with glucose

d) by HCO3- movement

7) Transport Maximum, in urinary system terms, refers to

a) proteins performing âtransportâ out of the filtrate at maximum rate

b) the reason why a diabetic produces large volumes of diluted urine

c) excess filtrate components being urinated out of the body

d) All choices are correct

8) Urine does not drop below pH 4.5 because

a) proteins that move H+ into filtrate stop working when too much H+ builds up in filtrate

b) proteins in urine neutralize acid

c) H+ are always buffered

d) the buffering system in urine does not run out

9) Hyperkalemia will

a) activate adrenal cells to secrete aldosterone

b) can stop the heart

c) No choices are correct

d) cause reduced excitability of neurons

e) All choices are correct

10)In your body, chloride (Cl-) can be found in its highest concentration in

a) extracellular fluid

b) intracellular fluid

c) Neither choice is correct

11) Diuretic abuse leads to

a) All choices are correct

b) two choices are correct

c) No choice is correct

d) dehydration

e) athletes being accused of doping

f) hypotonic hydration

12) Long diffusion distance, low blood pressure, and impaired circulation are the result of

a) hypernatremia

b) edema

c) hyperkalemia

d) water toxicity

13) In males FSH is under feedback control by _____ and is down regulated when _________reaches high concentrations

a) inhibin, testosterone/sperm #s

b) testosterone, inhibin/sustentocyte #s

c) ADH, inhibin/sustentocyte #s

d) LH, testosterone/sperm #s

14) Testosterone production is done by ____-cells

a) posterior pituitary

b ) interstitial endocrine

c) anterior pituitary

d) sustentocytes

15) Upon _____of estrogen/progesterone, the ____phase of the uterine cycle begins

a) increase; menstrual

b) decrease; menstrual

c) increase; proliferative

d) decrease; secretory

16) Progesterone

a) All choices are correct

b) is low in the luteal phase

c) No choices are correct

d) raises in the follicular phase

e) is high along with estrogen during the follicular phase

17) Which nephron is most responsible for urine concentration?

a) cortical nephrons

b) Juxtamedullary nephrons

c) Neither

carminesalmon877

1. MarthaÃ¢â¬â¢s first patient on the pediatric floor is a 12-year oldboy named Sam who is undergoing kidney dialysis treatment. Sam hasbeen on dialysis for the last week, and the treatments willprobably be discontinued because his kidneys are becoming fullyfunctional again. Martha questions SamÃ¢â¬â¢s mother concerning hisillness. Three weeks ago, Sam had a sore throat, which kept himhome from school for two days but was not medically treated. Oneweek ago, Sam told his mother his urine looked red-brown and foamy.He was admitted to the hospital. Physical exam revealedcostovertebral tenderness and blood pressure of 135/90. Theurinalysis and other studies revealed the following:

Color: red-brown tinged
Specific gravity: 1.030
RBCÃ¢â¬â¢s: numerous RBCÃ¢â¬â¢s per high powered field
Protein: > 1g/24 hr
Casts: epithelial cells and RBCÃ¢â¬â¢s
BUN: 90 mg/dl
Creatinine: 4mg/dl
Creatine Clearance Test: 50 ml/min

a. What is your diagnosis?
i. Glomerulonephritis
ii. Cystitis
iii. Urinary obstruction
iv. Pyelitis

b. The etiology would be a(n):
i. Virus
ii. Bacteria
iii. Genetic or developmental anomaly
iv. Anatomic malfunction after birth

2. Fred suffers from chronic emphysema. His arterial blood gasresults are as follows: pH 7.30; bicarbonate 32 mEq/l; PCO2 50 mmHg. Which of the following best describe FredÃ¢â¬â¢s condition?
a. Metabolic acidosis with respiratory compensation
b. Respiratory acidosis with metabolic compensation
c. Metabolic alkalosis with respiratory compensation
d. Respiratory alkalosis with metabolic compensation

3. Hypocalcaemia may develop in a patient with which of thefollowing conditions?
a. Chronic renal failure
b. Hyperparathyroidism
c. Thiazide therapy
d. Vitamin D overdose

4. Which of the following conditions would cause prerenalfailure?
a. Nephrotoxicity
b. Glomerulonephritis
c. Acute tubular necrosis
d. Hypovolemia

5. Abnormal serum laboratory findings common to patients with acuterenal failure are:
a. Increased potassium and BUN; decreased creatinine
b. Increased potassium and creatinine; decreased BUN
c. Decreased potassium; increased BUN and creatinine
d. Increased potassium, BUN and creatinine

6. In the diuretic phase of acute tubular necrosis (ATN), theclinician must be alert for which of the followingcomplications?
a. Fluid overload
b. Hypokalemia
c. Hypertension
d. Hypernatremia

7. The primary acid-base disorder associated with renal failureis:
a. Respiratory acidosis
b. Metabolic acidosis
c. Respiratory alkalosis
d. Metabolic alkalosis

8. Patients with acute renal failure may have all of the followingcomplications EXCEPT:
a. Peaked T wave EKG and pericarditis
b. Sinus tachycardia and ST elevation
c. Heart failure and Friction rub
d. Mitral insufficiency and Mobitz type II heart block

9. A patientÃ¢â¬â¢s glomerular filtration rate can be measure byevaluating:
a. Serum creatinine
b. Blood urea nitrogen
c. Serum osmolarity
d. Creatinine clearance

10. A patient taking medication that acts to block or inhibit theaction of aldosterone would:
a. Have high blood potassium levels
b. Have high blood sodium levels
c. Have high levels of circulating aldosterone
d. A, B, and C
e. A and C only

11. A patient exhibits the following signs and symptoms: Elevatedblood pressure, elevated blood glucose, muscle weakness, poor woundhealing, red cheeks, thin arms and legs with fat deposits in thetrunk, neck and face. The patient findings are consistentwith:
a. AddisonÃ¢â¬â¢s Disease
b. Myxedema
c. CushingÃ¢â¬â¢s disease or long-term high dose steroid use
d. GraveÃ¢â¬â¢s disease
e. Pheochoromocytoma

12. The MOST dramatic functional change that occurs in theendocrine system due to aging is
a. A decrease in blood and tissue concentrations of ADH andTSH
b. And overall decrease in circulating levels of mosthormones.
c. A decline in the concentration of reproductive hormones
d. And increase in the secretion of glucocortioids

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BIOL 1105 Lecture Notes - Lecture 10: Hypertension, Urethra, Aquaporin

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