BIOL 1105 Lecture Notes - Lecture 17: X-Inactivation, Carl Correns, Walter Sutton
Document Summary
Lesson 17 inheritance of genetic information ii. Morgan: provided first evidence that genes resided on chromosomes. Hemophilia: affects a single protein in the cascade of proteins involved in the formation of blood clots, form of hemophilia is caused by an x-linked recessive allele, heterozygous females are carriers. Dosage compensation: ensures equal expression of genes from the sex chromosomes even through females have 2 x chromosomes and males have 1. In each female cell, 1 of the x chromosomes is inactivated and is highly condensed into a barr body. X chromosome inactivation and genetic mosaics: females heterozygous for genes on the x chromosome are genetic mosaics, different cells express different alleles depending on which x chromosome is inactivated. Exceptions to chromosomal theory of inheritance: mitochondria and chloroplasts genomes, traits controlled by these organelle genes do not follow the cti, mitochondria are inherited from the mother, chloroplasts often inherited by the mother, but is species dependent.
