HNFE 3025 Lecture Notes - Lecture 4: Pyruvate Dehydrogenase, Acetyl-Coa, Glutaric Acid
16 Jul 2016
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Document Summary
Hexokinase is reversible while glucokinase is not reversible. Pfk-1 is a major regulatory point, inhibited by citrate (first step of tca cycle, when it builds up when we don"t have a high energy demand along with an atp buildup) and atp; this stops glycolysis. Amp and adp send signal that we are low in energy. Pyruvate kinase atp + acetyl coa inhibit pyruvate kinase. Isocitrate and alpha ketoglutarate are in charge of nadh production; they generate. Nadh for the etc, calcium comes in when high energy demand and increases isocitrate + alpha keto glutarate. Type 2 muscle is white, fast twitch, g3p shuttle. Type 1 is red muscle, slow, malate aspartate shuttle. Takes electrons from glycolysis in the form of nadh and take it to the etc. G3p has a lower km; this is more of an ancient system, it is faster. Pyruvate dehydrogenase- shuttle 2 nadh from glycolysis to mitochondria.
